First Line Therapy in Type 2 Diabetes

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Quick Medical Review

Education


In this Episode of our type 2 diabetes education series, we discuss pharmacologic management, focusing on first-line therapy. Metformin remains foundational unless contraindicated, thanks to its weight-neutrality, low hypoglycemia risk, and cardiovascular benefits. Recent advancements position SGLT2 inhibitors alongside metformin for patients with cardiovascular disease, heart failure, chronic kidney disease, or high cardiovascular risk. They offer glucose-lowering effects and improve cardiovascular and renal outcomes. Important considerations include titrating metformin to minimize side effects, understanding sick-day rules, and being aware of diabetic ketoacidosis symptoms. Rescue therapy with insulin or sulphonylurea is discussed for symptomatic hyperglycemia. Tune in for a detailed guide on modern first-line therapy for type 2 diabetes and prepare for our next episode on intensification strategies.


00:00 Introduction to Type 2 Diabetes Series

00:21 First-Line Therapy: Metformin

00:48 Emerging Front-Line Therapy: SGLT2 Inhibitors

01:18 Case Studies and Practical Applications

01:43 Managing Patients Who Cannot Tolerate Metformin

02:04 Important Considerations for SGLT2 Inhibitors

02:33 Clinical Example: Chronic Kidney Disease

03:00 Rescue Therapy for Symptomatic Hyperglycemia

03:21 Summary and Key Takeaways

04:15 Looking Ahead: Intensification of Therapy

04:35 Conclusion and Next Steps