Protein misfolding plays a pivotal role in neurodegenerative diseases, where misfolded proteins aggregate, disrupting neuronal function and leading to cell death. Conditions such as Alzheimer's, Parkinson's, and Huntington's diseases are characterized by the accumulation of abnormal protein aggregates that impair cognitive and motor functions. Understanding the mechanisms of protein misfolding is crucial for developing targeted therapies aimed at preventing or reversing these pathological processes, offering hope for more effective treatments for neurodegenerative disorders. Visit: https://www.gaintherapeutics.com/perspectives/the-role-of-protein-misfolding-in-neurodegenerative-diseases