Does once-weekly 2.4 milligram subcutaneous semaglutide plus lifestyle intervention reduce BMI more than lifestyle intervention alone in adolescents with obesity?

In adolescents with obesity, once-weekly 2.4 mg subcutaneous semaglutide plus lifestyle intervention reduced BMI more than lifestyle intervention alone over 68 weeks, by about 17 percentage points.

Randomized trial · NEJM 2022

Reference: Weghuber D, Barrett T, Barrientos-Pérez M. Once-Weekly Semaglutide in Adolescents with Obesity. N Engl J Med. 2022; PMID:36322838.

Chapters

0:00 Intro

0:38 The trial

3:14 My take

3:43 Outro

Read the structured trial summary at https://hormoneinsight.com/

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