Education
Can once-weekly semaglutide produce meaningful weight loss in adults with obesity?
In this 2-minute evidence brief, we break down the STEP 1 trial, a randomized double-blind clinical trial published in the New England Journal of Medicine in 2021. The study tested semaglutide 2.4 mg once weekly versus placebo, both with lifestyle intervention, in adults with overweight or obesity but without diabetes.
Covered in this video:
- Why the STEP 1 trial was done
- How the trial was conducted
- Main weight loss results
- Safety and gastrointestinal side effects
- Key clinical takeaway
Main result: average body weight decreased by 14.9% with semaglutide versus 2.4% with placebo over 68 weeks.
Citation:
Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021.
PMID: 33567185
DOI: 10.1056/NEJMoa2032183
This video is for medical education only and does not replace clinical judgment or individual medical advice.
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