Sergei Mirkin, Tufts University, Medford, speaks on "Mechanisms of genome instability mediated by interstitial telomeric sequences". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.

At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy

S. Mirkin - Mechanisms of genome instability mediated by interstitial telomeric sequences

The conference will represent a unique forum to discuss the most recent and unpublished findings on the basic biology of replication fork perturbation and repair as well as on our current understanding of how replicative stress drives cancer and aging. Session topics will include: Basic mechanisms at the replication fork, Replication-repair interface, Replication fork remodeling, Structural and single molecule analysis of replication/repair, Replication-transcription interface, Replication-recombination interface Chromatin, replication and genome maintenance, Difficult-to-replicate loci and telomers, Replication stress in cancer onset and therapy.

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At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy