We discuss all sorts of quandaries and myths related to lumbar punctures and CSF interpretation with Dr Prashanth Ramachandran. Specific topics covered include: lumbar punctures on antiplatelets/anticoagulants, lumbar punctures in the setting of intracranial masses, post-LP leptomeningeal enhancement, investigation of acute meningoencephalitis, investigation of chronic meningoencephalitis, acellular elevated protein, chronic idiopathic meningitis, post-ictal lymphocytic pleocytosis and HaNDL.