Can levothyroxine be discontinued in older adults with subclinical hypothyroidism?

In a pilot randomised trial, stopping low-dose levothyroxine did not change hypothyroid symptoms, tiredness or quality of life over six months compared with continuing treatment.

Pilot randomised trial · Endocrine 2025

Reference: Maraka S, et al. Discontinuation of levothyroxine therapy in patients with subclinical hypothyroidism: a pilot randomised clinical trial. Endocrine. 2025;90(2):781-792. doi:10.1007/s12020-025-04371-z. PMID: 40736623. https://pubmed.ncbi.nlm.nih.gov/40736623/

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