Science
This paper explores the diverse applications of stem cells and cellular reprogramming strategies in regenerative medicine. It highlights the foundational understanding of stem cell biology that has led to advancements in generating various cell types for therapeutic use, including induced pluripotent stem cells (iPSCs). The article discusses ongoing clinical trials utilizing both naturally occurring and reprogrammed stem cells for conditions like diabetes, Parkinson's disease, and tissue repair. Furthermore, it examines the challenges and future directions of these approaches, such as addressing limitations in tissue regeneration and developing new strategies for repairing organs lacking robust stem cell pools. Overall, the text showcases stem cells as crucial models for understanding cell plasticity and developing innovative treatments. References: * Götz M, Torres-Padilla M E. Stem cells as role models for reprogramming and repair[J]. Science, 2025, 388(6746): eadp2959.